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This book provides an insightful analysis of the chemopreventive actions of flavonoids. Flavonoids are naturally occurring constituents of plants that have been traditionally used as anti-inflammatory and anti-cancer medicines. In addition, human consumption of vegetables and fruits with high concentrations of flavonoids is associated with decreased cancer mortalities rates. Flavonoids, Inflammation and Cancer presents an in-depth analysis of the mechanisms by which flavonoids are thought to prevent inflammation and the development of GI and steroid-responsive cancers.
Vaccine-A uncovers a story of betrayal – the betrayal of the men and women who serve in the armed forces, the betrayal of medical ethics, and the betrayal of the American people by military and civilian leaders sworn to defend and protect. Veteran journalist Gary Matsumoto shows that the worst friendly-fire incident in military history came from something no soldier had any reason to think would harm him: a vaccine administered by the military’s own medics. When troops went to the Middle East to fight the Gulf War in 1991 and the Iraq War in 2003, many – perhaps thousands – received an experimental anthrax vaccine instead of the FDA-approved vaccine.
This book provides a comprehensive, up-to-date and critical overview of the immunological aspects of autoimmune neurological disease. These diseases include common conditions such as multiple sclerosis, the Guillain-Barre syndrome, and myasthenia gravis. The book begins with chapters on antigen recognition and self-nonself recognition, and neuroimmunology, followed by chapters on specific diseases. For each disease, the authors cover clinical features, genetics, neuropathology, pathophysiology, immunology, and therapy.
Authors: Escors, D., Talmadge, J.E., Breckpot, K., Van Ginderachter, J.A., Kochan, G.Comprehensively explores the biology and role of MDSCs in cancerCovers therapeutic targeting via the STAT3 pathway, a major regulatory pathway in MDSCs functions as well as in tumour cellsParticularly relevant for scientists working in the pharmaceutical industry and in oncology researchThe book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting.
p53 has emerged as a key tumor suppressor and important target for novel cancer therapy. This book, written by world-leading p53 researchers including many of those who have shaped the field over the past 25 years, provides unique insights into the progress of the field and the prospects for better cancer diagnosis and therapy in the future.
Neuroimmune pharmacology seeks to harness the immune system to provide pharmacological intervention to combat neurodegenerative diseases. This book provides a comprehensive overview of topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders.
The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system’s first line of defence works, to breakthroughs in crystallography and the exploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation and allergy.T
Understanding the immune system is crucial for both medical and bioscience students, with new research revealing yet more secrets year on year. Many books offer in–depth introductions to the subject, but How the Immune System Works remains uniquely popular for its personable and practical overview of the nuts and bolts of the immune system. This third edition provides a perfect introduction to the essential principles of the immune system, covered in humorous but highly informative ′lectures′ accompanied by clear and accessible illustrations.
This newly reorganized and expanded Second Edition of the revolutionary reference guide, Atopic Dermatitis, is the only available text devoted to discussing all aspects of this common disease. Appealing to dermatologists, allergists, family practitioners, and pediatricians in daily practice, as well as physician scientists, medical students, and experimental investigators, this stand-alone guide addresses recent breakthrough discoveries in genetics and new milestones in immunological research in dermatology.N
Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy.
Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. The book brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer.
This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance.
This volume brings together the skills and protocols of numerous laboratories that are at the heart of investigation into the biology of Tfh cells in both mice and humans. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.
Concise and easy-to-use, T follicular Helper Cells: Methods and Protocols provides scientist with techniques and protocols that have facilitated breakthroughs in Tfh biology and to present them in a way that will enable both new and experienced researchers to continue to move this exciting field forward.
In this most comprehensive reference source for the development, production and therapeutic application of antibodies, Volume I contains general chapters presenting established technologies and clinical applications. Volume II provides a look at emerging technologies, new therapeutic concepts, and clinical studies. The third volume features detailed and specific information about each currently approved type of antibody, including the clinical data. A must-have resource for academic researchers, decision makers in industry and healthcare professionals in the clinic.
This book intends to be neither a complete survey of the field nor an exhaustive source of references. For these purposes, the use of the extensive compilation "Experimental Immunochemistry" by E. A. KABAT and M. M. MAYER (1962) or the excellent methodological textbook, "Methods in Immunology", by D. H. CAMPBELL, J. S. GARVEY, E. E. CREMER and D. H. SUSSDORF (1963), or the quite comprehensive series "Methods in Immunology and Immunochemistry" by C. A. WILLIAMS and M.
In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense―and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself.
The second edition of this popular book has been extensively rewritten and up-dated. As well as being an essential introductory text for beginners to this field, it is also of interest to more experienced workers wishing to refresh their knowledge. ; ; Im
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