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Statistical methods are a key ingredient in providing data–based guidance to research and development as well as to manufacturing. Understanding the concepts and specific steps involved in each statistical method is critical for achieving consistent and on–target performance.
Hermann Sicius stellt in diesem "essential" die Elemente der sechsten Nebengruppe (Chromgruppe) ausfuhrlich vor. Er zeigt, dass die Elemente dieser Gruppe chemisch meist relativ reaktionstrage sind und regelmassige Abstufungen ihrer Eigenschaften zeigen. So nehmen vom Chrom zum Wolfram Dichte, Schmelz- und Siedepunkte zu, die Reaktivitat leicht ab. Chrom, Molybdan und Wolfram entdeckte man Ende des 18. Jahrhunderts, das nur kunstlich darstellbare Seaborgium erst etwa 200 Jahre spater.
Wie der Autor in diesem einführenden Lehrbuch, das auch ohne Vorwissen verständlich ist, schreibt, ist die Chemie "die schönste Unbekannte unter den Wissenschaften". Gerade das Unbekannte aber ängstigt uns am meisten. Das Buch versucht, den Blick für den Reiz dieser faszinierenden Naturwissenschaft zu schärfen und sie so begreifbar zu machen. Dabei hilft eine Darstellung, die auf Vorkenntnisse weitgehend verzichtet. Zahlreiche einfache Versuche vertiefen das Verständnis, Formeln bleiben auf ein Minimum beschränkt.
Reflecting the growing volume of published work in this field, researchers will find this book an invaluable source of information on current methods and applications.
Each entry contains the name of the component, the chemical and physical characteristics, a description of functional properties related to food use, and nutritional and toxicological data. Ample references facilitate inquiry into more detailed information about any particular compound.
The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This book explores the evolving definition of innovation in therapeutic product development and begins to examine its effects on the life sciences R&D industry.
Historically, scientific innovation alone was sufficient to maintain ROI and deliver on unmet medical needs. However, with many forces now conspiring to increase pressures on the commoditization of drug development, industry support for truly novel, often high-risk development has eroded. This calls for a drastic redefinition of what “innovation” is. While innovation in the pharmaceutical R&D industry has historically been applied to major advances in therapy and unmet medical needs, we now need to see innovation increasingly defined in terms of financial, marketing (e.g. branded generics and emerging markets), pharmacoeconomic, and operational innovation.
In this book, contributors drawn from the executive ranks of clinical development practitioners and stakeholders―from biopharmaceutical companies, clinical research organizations, academia, the financial community, and the patient perspective―have all come together to provide their expertise and visions. Their goal is to start a dialogue about ways to radically improve therapeutics development and get more and better medicines to the patients who need them, as fast as possible, in the most cost-efficient manner.
Ana Escribano Cuesta’s thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared.
Chemistry: The Molecular Nature of Matter and Change by Martin Silberberg has been recognized in the general chemistry market as an unparalleled classic. The seventh edition keeps pace with the evolution of student learning by adding and significantly enhancing sample problems, a key resource of students. The text still contains unprecedented macroscopic-to-microscopic molecular illustrations, consistent step-by-step worked exercises in every chapter, and an extensive range of end-of-chapter problems, which provide engaging applications covering a wide variety of interests, including engineering, medicine, materials, and environmental studies.
In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes).
Derived from the best-selling classic text originated by Lubert Stryer and continued by John Tymoczko and Jeremy Berg, Biochemistry: A Short Course focuses on the major topics taught in a one-semester biochemistry course. With its short chapters and relevant biological and clinical examples, this text shows biochemistry as a part of students’ everyday lives. Offering the same signature writing style and physiological emphasis as the full-length text, this briefer book focuses on the major topics by eliminating details of enzyme mechanisms and organic chemistry, and by removing extraneous and advanced topics.
Provide clear guidance to the 2014 changes and ensure in-depth study with accessible content, directly mapped to the new syllabus and approach to learning This second edition of the highly-regarded first edition contains all SL and HL content, which is clearly identified throughout. Options are available free online, along with appendices and data and statistics. – Improve exam performance, with exam-style questions, including from past papers – Integrate Theory of Knowledge into your lessons and provide opportunities for cross-curriculum study – Stretch more able students with extension activities – The shift to concept-based approach to learning , Nature of Science, is covered by providing a framework for the course with points for discussion – Key skills and experiments included – Full digital package – offered in a variety of formats so that you can deliver the course just how you like!
This book gives background information why shale formations in the world are important both for storage capacity and enhanced gas recovery (EGR). Part of this book investigates the sequestration capacity in geological formations and the mechanisms for the enhanced storage rate of CO2 in an underlying saline aquifer.The growing concern about global warming has increased interest in geological storage of carbon dioxide (CO2). The main mechanism of the enhancement, viz., the occurrence of gravity fingers, which are the vehicles of enhanced transport in saline aquifers, can be visualized using the Schlieren technique.
This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in–depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics.
Authors: Innocenzi, PlinioExplains the sol to gel transition, a subject of wide interest, in a clear and concise mannerFeatures a simple and intuitive approach to make the material accessible and enjoyable for chemistry students through active researchersRepresents the first book-length treatment of the topicThis book provides an in-depth introduction to the sol to gel transition in inorganic and hybrid organic-inorganic systems, one of the most important chemical-physical transitions and the basis of the sol-gel process.
Advancements in photopolymers have led to groundbreaking achievements in the electronics, print, optical engineering, and medical fields. At present, photopolymers have myriad applications in semiconductor device manufacturing, printed circuit boards (PCBs), ultraviolet (UV) curing, printing plates, 3-D printing, microelectromechanical systems (MEMS), and medical materials. Processes such as photopolymerization, photodegradation, and photocrosslinking, as well as lithography technology in which photofabrications are performed by images of photopolymers, have given rise to very large-scale integrated (VLSI) circuits, microproducts, and more.A
Advances in the Theory of Quantum Systems in Chemistry and Physics is a collection of 32 selected papers from the scientific contributions presented at the 15th International Workshop on Quantum Systems in Chemistry and Physics (QSCP-XV), held at Magdalene College, Cambridge, UK, from August 31st to September 5th, 2010. This volume discusses the state of the art, new trends, and the future of methods in molecular quantum mechanics and their applications to a wide range of problems in chemistry, physics, and biology.
Janet Lau’s thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration.
Goodbye, genetic blueprint. . . . The first book for general readers ?on the game-changing field of epigenetics. The burgeoning new science of epigenetics offers a cornucopia of insights—some comforting, some frightening. For example, the male fetus may be especially vulnerable to certain common chemicals in our environment, in ways that damage not only his own sperm but also the sperm of his sons. And it’s epigenetics that causes identical twins to vary widely in their susceptibility to dementia and cancer.
For four decades, this extraordinary textbook played a pivotal role in the way biochemistry is taught, offering exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. Those defining features are at the heart of this edition.
The inspiration for this book came from an American Carbon Society Workshop entitled "Carbon Materials for Advanced Technologies" which was hosted by the Oak Ridge National Laboratory in 1994. Chapter 1 contains a review of carbon materials, and emphasizes the structure and chemical bonding in the various forms of carbon, including the four allotropes diamond, graphite, carbynes, and the fullerenes. In addition, amorphous carbon and diamond films, carbon nanoparticles, and engineered carbons are discussed.
"Surface Preparation Techniques for Adhesive Bonding" is an essential guide for materials scientists, mechanical engineers, plastics engineers, scientists and researchers in manufacturing environments making use of adhesives technology.
Scientists and engineers must use methods of probability to predict the outcome of experiments, extrapolate results from a small case to a larger one, and design systems that will perform optimally when the exact characteristics of the inputs are unknown.
The audience for this thorough overview includes advanced undergraduates and postgraduate researchers in macromolecular sciences who can benefit from more familiarity with the use of X-ray diffraction for obtaining structural information on biological substances, natural and synthetic high polymeric materials.
Maintaining the clear, approachable writing style characteristic of author Karen Timberlake, Basic Chemistry , Fourth Edition, adds to its suite of problem-solving tools and techniques necessary for success in chemistry. Engaging new features such as end-of-section Math Practice problems, video tutorials and Math Review Modules allow readers to practice and master quantitative skills. Popular features, including “Combining Ideas” sections and end-of-chapter questions, have also been strengthened and expanded.
Showing 1–24 of 172 results