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The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to fill the gap. This book explores the evolving definition of innovation in therapeutic product development and begins to examine its effects on the life sciences R&D industry.
Historically, scientific innovation alone was sufficient to maintain ROI and deliver on unmet medical needs. However, with many forces now conspiring to increase pressures on the commoditization of drug development, industry support for truly novel, often high-risk development has eroded. This calls for a drastic redefinition of what “innovation” is. While innovation in the pharmaceutical R&D industry has historically been applied to major advances in therapy and unmet medical needs, we now need to see innovation increasingly defined in terms of financial, marketing (e.g. branded generics and emerging markets), pharmacoeconomic, and operational innovation.
In this book, contributors drawn from the executive ranks of clinical development practitioners and stakeholders―from biopharmaceutical companies, clinical research organizations, academia, the financial community, and the patient perspective―have all come together to provide their expertise and visions. Their goal is to start a dialogue about ways to radically improve therapeutics development and get more and better medicines to the patients who need them, as fast as possible, in the most cost-efficient manner.
Chemistry: The Molecular Nature of Matter and Change by Martin Silberberg has been recognized in the general chemistry market as an unparalleled classic. The seventh edition keeps pace with the evolution of student learning by adding and significantly enhancing sample problems, a key resource of students. The text still contains unprecedented macroscopic-to-microscopic molecular illustrations, consistent step-by-step worked exercises in every chapter, and an extensive range of end-of-chapter problems, which provide engaging applications covering a wide variety of interests, including engineering, medicine, materials, and environmental studies.
In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes).
Provide clear guidance to the 2014 changes and ensure in-depth study with accessible content, directly mapped to the new syllabus and approach to learning This second edition of the highly-regarded first edition contains all SL and HL content, which is clearly identified throughout. Options are available free online, along with appendices and data and statistics. – Improve exam performance, with exam-style questions, including from past papers – Integrate Theory of Knowledge into your lessons and provide opportunities for cross-curriculum study – Stretch more able students with extension activities – The shift to concept-based approach to learning , Nature of Science, is covered by providing a framework for the course with points for discussion – Key skills and experiments included – Full digital package – offered in a variety of formats so that you can deliver the course just how you like!
Maintaining the clear, approachable writing style characteristic of author Karen Timberlake, Basic Chemistry , Fourth Edition, adds to its suite of problem-solving tools and techniques necessary for success in chemistry. Engaging new features such as end-of-section Math Practice problems, video tutorials and Math Review Modules allow readers to practice and master quantitative skills. Popular features, including “Combining Ideas” sections and end-of-chapter questions, have also been strengthened and expanded.
Filling a gap in our systematic knowledge of gold, this monograph covers the fundamental aspects, while also considering new applications of gold compounds in catalysis, as nanoparticles, and their potential application as luminescent compounds.Written by an eminent team of authors from academia, the book analyzes the current status of gold chemistry, its special characteristics, oxidation states and main type of complexes, before going on to look at the synthesis of supramolecular aggregates due to the formation of gold-gold, gold-metal interactions or other secondary bonds.
Nanotechnology is the key technology of the 21st century. The possibility to exploit the structures and processes of biomolecules for novel functional materials, biosensors, bioelectronics and medical applications has created the rapidly growing field of nanobiotechnology.Designed as a broad survey of the field, this book combines contributions from bioorganic and bioinorganic chemistry, molecular biology, materials science and bioanalytics to fathom the full scope of current and future developments.I
During the second half of the nineteenth century and the beginning of the twentieth century chemical societies were established all over Europe. The book focuses on this process and further development of the European chemical societies before World War I and in exceptional cases up to 1930.
The study of surfaces has experienced dramatic growth over the past decade. Now, the editors of the internationally celebrated series Advances in Chemical Physics have brought together in this self-contained, special topic volume contributions from leading researchers in the field treating some of the most crucial aspects of the experimental and theoretical study of surfaces. This work delves into such core issues as: Kinetics and dynamics of hydrogen adsorption on silicon surfaces. Potential energy surfaces of transition- metal-catalyzed chemical reactions.
Wine Flavour Chemistry brings together a vast wealth of information describing components of wine, their underlying chemistry and their possible role in the taste, smell and overall perception. It includes both table wines and fortified wines, such as Sherry, Port and the newly added Madeira, as well as other special wines. This fully revised and updated edition includes new information also on retsina wines, rosés, organic and reduced alcohol wines, and has been expanded with coverage of the latest research.
From atoms and fluorescent pigments to sulfa drug synthesis and buckyballs, this lush and authoritative chronology presents 250 milestones in the world of chemistry. As the "central science" that bridges biology and physics, chemistry plays an important role in countless medical and technological advances. Covering entertaining stories and unexpected applications, chemist and journalist Derek B. Lowe traces the most important—and surprising—chemical discoveries.
"The Facts On File Biology Handbook, Revised Edition" offers students a full view of this vital branch of science, in the form of a one-stop reference, with more than 1,700 glossary entries.
The use of hazardous chemicals such as methyl isocyanate can be a significant concern to the residents of communities adjacent to chemical facilities, but is often an integral part of the chemical manufacturing process. In order to ensure that chemical manufacturing takes place in a manner that is safe for workers, members of the local community, and the environment, the philosophy of inherently safer processing can be used to identify opportunities to eliminate or reduce the hazards associated with chemical processing.
This book will be of interest to biotechnology professionals, processors, scientists, nutritionists, economists, new product development and business professionals, official agencies, and others actively engaged in the development and marketing of value-added products.
Principles and Practices of Polymer Mass Spectrometry helps readers acquire the skills necessary for selecting the optimal methods, handling samples, analyzing the data, and interpreting the results of the mass spectrometry of polymers. This guide describes the principles of polymer MS and best practices in polymer characterization. It discusses different approaches, including MALDI, ESI, TOF MS, and FT-MS. It provides a guide to developing appropriate sample preparation protocols for different polymers.
Antimicrobial polymers are materials that prevent microorganism growth and are needed for many everyday applications from food packaging and water treatment to medicine and healthcare. This new book covers different areas of antimicrobial materials based on polymers including chitosan, polymers with ammonium and phosphonium groups, polymer nanofibers, carbon-based polymer Nanocomposites, polymeric and non-polymeric metal complexes, and biomimetic materials. By combining the information of different materials as well as antimicrobial action modes and applications within one source, the book provides a general summary of the field.P
A unique textbook, aimed at undergraduate students, containing large numbers of spectra, problems and marginal notes, specifically chosen to highlight the points being discussed.
The Logic of Chemical Synthesis The title of this three-part volume derives from a key theme of the book-the logic underlying the rational analysis of complex synthetic problems. Although the book deals almost exclusively with molecules of biological origin, which are ideal for developing the fundamental ideas of multistep synthetic design because of their architectural complexity and variety, the approach taken is fully applicable to other types of carbon-based structures. Part One outlines the basic concepts of retrosynthetic analysis and the general strategies for generating possible synthetic pathways by logical reduction of molecular complexity.
History of thought on molecular origins of surface phenomena offers a critical and detailed examination and assessment of modern theories, focusing on statistical mechanics and application of results in mean-field approximation to model systems. Emphasis on liquid-gas surface, with a focus on liquid-liquid surfaces in the final chapters. 1989 edition.
Most people remember chemistry from their schooldays as largely incomprehensible, a subject that was fact-rich but understanding-poor, smelly, and so far removed from the real world of events and pleasures that there seemed little point, except for the most introverted, in coming to terms with its grubby concepts, spells, recipes, and rules. Peter Atkins wants to change all that.
In this Very Short Introduction to Chemistry, he encourages us to look at chemistry anew, through a chemist’s eyes, in order to understand its central concepts and to see how it contributes not only towards our material comfort, but also to human culture.
The reception of the periodic system of elements has received little attention. Many historians have studied Mendeleev’s discovery of the periodic system, but few have analyzed how the scientific community perceived and employed it. American historian of science Stephen G. Brush concluded that the periodic law had been generally accepted in the United States and Britain and suggested the need to extend this study to other countries.
Early Responses to the Periodic System is the first collection of comparative studies on the reception, response, and appropriation of the periodic system of elements.
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